It is so important that we talk about the mental health aspect of perimenopause, because, honestly, the physical symptoms are almost easier to deal with than the feeling that you’re losing your mind. When estrogen starts to disappear, it takes a huge chunk of our serotonin and dopamine with it. Those are the “feel-good” chemicals that keep us stable, patient, and focused. Without them, you aren’t just “moody”. You’re dealing with a legitimate biochemical shift that can trigger deep depression or a level of anxiety that feels like a constant humming motor under your skin.